Immunoglobulin G glycosylation and its alterations in aging-related diseases

• IgG glycosylation alterations, including reduced galactosylation and sialylation and increased agalactosylation and bisecting GlcNAc, are key biomarkers of aging and age-related diseases. • Glycan changes on IgG modulate its pro- or anti-inflammatory properties, linking IgG glycosylation to chronic inflammation in aging. • The review consolidates current knowledge on IgG glycosylation in normal aging and age-related diseases, highlighting its potential for diagnostic and therapeutic strategies. • Understanding IgG glycosylation regulatory mechanisms may enable the development of glycan-based biomarkers and interventions for aging-related conditions.