Official PDF Translation•Acta Biochimica et Biophysica Sinica

Identification and validation of disease severity-related circular RNA in acute pancreatitis

Authors: Jiarong Li; Zefang Sun; Caihong Ning; Chiayen Lin; Dingcheng Shen; Gengwen Huang; Shuai Zhu; Lu Chen

DOI: 10.3724/abbs.2024115Status: Verified Translated Edition

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Key Findings in This Report

• Identified 91 differentially expressed circRNAs in acute pancreatitis blood, with 81 downregulated and 10 upregulated. • Validated circ_0007798, circ_0001847, and circ_0069748 as significantly lower in acute pancreatitis patients. • circ_0007798 levels correlate with disease severity, suggesting its potential as a biomarker for grading acute pancreatitis. • circ_0007798 shows high conservation between rats and humans, indicating translational relevance.