Hydrogel loaded with fibroblast exosomes promotes endothelial cell function recovery and diabetic wound healing

• Fibroblast exosome-loaded PF-127 hydrogel significantly enhances proliferation, migration, and tube formation of human umbilical vein endothelial cells under high glucose conditions. • The hydrogel inhibits ferroptosis in endothelial cells, as evidenced by reduced lipid peroxidation and improved mitochondrial morphology. • In a diabetic rat model, the hydrogel accelerates wound closure and improves healing quality, with increased CD31-positive angiogenesis. • The therapeutic mechanism involves suppression of ferroptosis and restoration of endothelial cell function, offering a novel strategy for diabetic wound treatment.