Key Takeaways & Executive Findings
- •• Huperzine A attenuates neurological deficits after spontaneous subarachnoid hemorrhage by inhibiting endothelial cell pyroptosis. • The study identifies endothelial cell pyroptosis as a key therapeutic target in subarachnoid hemorrhage. • Huperzine A may offer a novel neuroprotective strategy for patients with subarachnoid hemorrhage. • The corrigendum ensures accurate attribution of authorship and affiliations for the original research.
Abstract
This is a corrigendum to the original article. The original article reported that Huperzine A ameliorates neurological deficits after spontaneous subarachnoid hemorrhage through endothelial cell pyroptosis inhibition. The corrigendum corrects errors in the author list and affiliations. The corrected authors and affiliations are provided.
1. Introduction
Spontaneous subarachnoid hemorrhage (SAH) is a devastating cerebrovascular event with high morbidity and mortality. Early brain injury, including endothelial cell dysfunction and neuroinflammation, contributes to poor outcomes. Pyroptosis, a pro-inflammatory form of programmed cell death, has been implicated in the pathogenesis of SAH. Huperzine A, an alkaloid derived from the Chinese club moss Huperzia serrata, has demonstrated neuroprotective properties in various neurological disorders. This study aimed to investigate whether Huperzine A could ameliorate neurological deficits after SAH by inhibiting endothelial cell pyroptosis.
The original article presented findings that Huperzine A treatment significantly reduced neurological deficits and attenuated endothelial cell pyroptosis in a mouse model of SAH. The corrigendum addresses errors in the author list and affiliations to ensure proper credit and transparency.
Loading authentic research manuscript (Pages 1–5)...
Qiang Hu, Rong Zhang, Xiaoqiao Dong, Dingbo Yang, Quan Du, Wenhua Yu (2026). Huperzine A ameliorates neurological deficits after spontaneous subarachnoid hemorrhage through endothelial cell pyroptosis inhibition. Acta Biochimica et Biophysica Sinica. https://doi.org/10.3724/abbs.2024037
Research & Educational Purpose Only:The translations, structured abstracts, analytical annotations, and data reports provided by SinoBioData are intended exclusively for academic research, internal corporate R&D, and educational benchmarking. They do not constitute formal engineering, chemical safety, legal, or professional advice.
Copyright & Intellectual Property Notice: Original copyright of the underlying source articles and experimental data remains with the respective authors, institutions, and original publishing journals. SinoBioData claims intellectual property only over its proprietary translations, analytical syntheses, and AEO structured enhancements in accordance with international fair use and academic citation principles.
Frequently Asked Questions
What is the main finding of the study on Huperzine A and subarachnoid hemorrhage?
The study found that Huperzine A ameliorates neurological deficits after spontaneous subarachnoid hemorrhage by inhibiting endothelial cell pyroptosis.
What is the significance of endothelial cell pyroptosis in subarachnoid hemorrhage?
Endothelial cell pyroptosis is a key pathological mechanism contributing to early brain injury and neurological deficits after subarachnoid hemorrhage, making it a potential therapeutic target.
What corrections were made in the corrigendum?
The corrigendum corrected errors in the author list and affiliations of the original article to ensure accurate attribution.
Where was the research conducted?
The research was conducted at the Department of Neurosurgery, The Affiliated Hangzhou Hospital of Nanjing Medical University, and Affiliated Hangzhou First People’s Hospital, School of Medicine, Westlake University, Hangzhou, China.
What is the DOI of the original article?
The DOI of the original article is 10.3724/abbs.2024037.
Related Technical Papers & Translations
Adverse Events Reporting System for Vaccine Safety Surveillance: A Comprehensive Analysis
Background: Adverse events following immunization (AEFI) are critical to monitor for vaccine safety. This study evaluates the performance of an adverse events reporting system (AERS) integrated with a vaccine adverse event reporting system (VAERS) to enhance surveillance. Methods: We analyzed data from multiple sources including the Vaccine Adverse Event Reporting System (VAERS), the Vaccine Safety Datalink (VSD), and the Clinical Immunization Safety Assessment (CISA) network. A novel framework was developed to integrate these systems, incorporating natural language processing for signal detection. Results: The integrated system improved detection of rare adverse events by 25% compared to traditional methods. The system identified new safety signals for influenza and COVID-19 vaccines. Conclusions: The proposed AERS framework enhances vaccine safety surveillance, enabling timely identification of potential risks. Integration of diverse data sources and advanced analytics is essential for robust pharmacovigilance.
Efficacy and Safety of Ferric Carboxymaltose in Treating Iron Deficiency Anemia: A Meta-Analysis of Randomized Controlled Trials
Background: Iron deficiency anemia (IDA) is a global health concern, and intravenous ferric carboxymaltose (FCM) has emerged as a promising treatment. This meta-analysis aimed to evaluate the efficacy and safety of FCM compared to other iron therapies or placebo in adults with IDA. Methods: We systematically searched PubMed, Embase, and Cochrane Library up to December 2024. Randomized controlled trials (RCTs) comparing FCM with active comparators or placebo in adults with IDA were included. The primary outcomes were change in hemoglobin (Hb) from baseline, and safety outcomes included adverse events (AEs) and serious adverse events (SAEs). Pooled estimates were calculated using random-effects models. Results: A total of 15 RCTs involving 4,856 patients were included. FCM significantly increased Hb levels compared to placebo (mean difference [MD] 1.2 g/dL, 95% CI 0.9-1.5) and was non-inferior to other intravenous iron preparations. The risk of AEs was similar between FCM and comparators (risk ratio [RR] 1.05, 95% CI 0.95-1.16), but FCM was associated with a lower risk of gastrointestinal AEs compared to oral iron. Serious adverse events were rare and comparable across groups. Conclusion: Ferric carboxymaltose is effective and safe for treating IDA, offering a convenient single-dose option with a favorable safety profile. These findings support its use in clinical practice.
Adverse Drug Reactions Associated with COVID-19 Vaccination: A Systematic Review and Meta-Analysis
Background: The rapid development and deployment of COVID-19 vaccines have been crucial in controlling the pandemic. However, adverse drug reactions (ADRs) associated with these vaccines have raised concerns. This systematic review and meta-analysis aimed to comprehensively evaluate the incidence and types of ADRs following COVID-19 vaccination. Methods: We systematically searched PubMed, Embase, and Cochrane Library from inception to December 2024. Randomized controlled trials and observational studies reporting ADRs after COVID-19 vaccination were included. A random-effects model was used to pool incidence rates, and subgroup analyses were performed by vaccine type and dose. Results: A total of 45 studies with 1,234,567 participants were included. The overall incidence of any ADR was 62.3% (95% CI: 58.1-66.4%). Common local reactions included injection site pain (48.2%), swelling (22.5%), and redness (18.7%). Systemic reactions included fatigue (34.6%), headache (28.9%), and myalgia (22.3%). Serious ADRs were rare (0.02%). Subgroup analysis showed higher incidence with mRNA vaccines compared to viral vector vaccines. Conclusion: COVID-19 vaccines are associated with a high incidence of mild-to-moderate ADRs, but serious ADRs are extremely rare. These findings support the overall safety of COVID-19 vaccination programs.