Histone acetylases are required for iron homeostasis in yeast

• Histone acetylases, but not methyltransferases, are required for proper iron homeostasis in yeast under iron-deficient conditions. • Deletion of specific histone acetylase genes (GCN5, RTT109, SAS2, YNG2) does not affect growth under iron deficiency, but may influence transcriptional induction of iron-responsive genes. • The study highlights the epigenetic regulation of iron metabolism, expanding the understanding of how histone modifications contribute to cellular adaptation to iron stress. • These findings have implications for treating iron-related disorders and for biotechnological applications in yeast.