Genome-Wide Association Study of Mutagenicity in Cancer: A Comprehensive Review

• GWAS have identified novel genetic loci associated with mutagenicity, implicating genes involved in DNA repair and cell cycle regulation. • Integration of functional genomics enhances the interpretation of GWAS hits, linking variants to molecular mechanisms. • Population-specific studies are crucial to address genetic diversity and improve risk prediction models. • Translating GWAS findings into clinical practice requires functional validation and multi-omics approaches.