Official PDF Translation•Acta Biochimica et Biophysica Sinica

GALNT7 promotes hepatocellular carcinoma progression by activating the PI3K/AKT signaling pathway via O-glycosylation of MUC13

Authors: Litao Liang; Chao Xu; Yunfeng Wang; Yanzhi Feng; Wenbo Jia; Jinyi Wang; Wenhu Zhao; Xiangyu Ling; Wenzhou Ding; Bing Han; Xiaoming Ai; Lianbao Kong; Yongping Zhou

DOI: 10.3724/abbs.2025117Status: Verified Translated Edition

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Key Findings in This Report

• GALNT7 is overexpressed in HCC tissues and correlates with enhanced tumor cell invasion, migration, proliferation, and reduced apoptosis. • GALNT7 specifically O-glycosylates MUC13, leading to activation of the PI3K/AKT signaling pathway, a key oncogenic driver in HCC. • Elevated GALNT7 levels confer resistance to lenvatinib-based chemotherapy, suggesting a role in therapeutic response. • The GALNT7-MUC13-PI3K/AKT axis represents a novel therapeutic target for HCC treatment.