• Caspr2 expression is significantly downregulated in dorsal root ganglion neurons following sciatic nerve injury, suggesting its involvement in the regenerative response.
• Knockdown of Caspr2 via siRNA promotes axonal growth in cultured dorsal root ganglion neurons, indicating an inhibitory role in axonal regeneration.
• Overexpression of Caspr2 suppresses axonal extension, further confirming its function as a negative regulator of axonal regeneration.
• Caspr2 represents a potential therapeutic target for enhancing peripheral nerve regeneration by modulating intrinsic neuronal growth capacity.