• Nanobiomedical materials demonstrate significant anti-inflammatory and pro-repair effects in osteoarthritis treatment, addressing limitations of conventional therapies.
• Nanocomposite materials integrate functions of different single nanomaterials, enabling multifunctional therapeutic agents for enhanced osteoarthritis management.
• Nanobiomedicine design leverages multi-responsive mechanisms (pH, enzyme, temperature) for precise and controlled drug release, improving therapeutic efficacy.
• Current research focuses on clinical translation, long-term safety, targeting precision, and standardized manufacturing of nanobiomedical approaches.