Official PDF Translation•Acta Biochimica et Biophysica Sinica

FOXM1 mediates methotrexate resistance in osteosarcoma cells by promoting autophagy

Authors: Luoyang Wang; Dongchang Zhai; Lei Tang; Hui Zhang; Xinlong Wang; Ning Ma; Xiaoyue Zhang; Mingguo Cheng; Ruowu Shen

DOI: 10.3724/abbs.2024084Status: Verified Translated Edition

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Key Findings in This Report

• FOXM1 is highly expressed in osteosarcoma tissues and methotrexate-resistant cells, contributing to drug resistance. • FOXM1 promotes methotrexate resistance by enhancing autophagy via the HMMR/ATG7 pathway. • Silencing FOXM1 or inhibiting autophagy reverses methotrexate resistance in osteosarcoma cells. • Targeting FOXM1 or autophagy represents a promising strategy to improve osteosarcoma chemotherapy outcomes.