Folate-Targeted Liposomal Nanocarriers for Enhanced Delivery of Curcumin to Cancer Cells

• Folate-targeted liposomes significantly enhance cellular uptake of curcumin in folate receptor-positive cancer cells, leading to improved cytotoxicity. • The developed FA-Lip-Cur formulation exhibits high encapsulation efficiency and sustained drug release, ensuring prolonged therapeutic effect. • Targeted delivery reduces off-target effects, as evidenced by lower IC50 in receptor-positive cells without affecting receptor-negative cells. • This nanocarrier system offers a viable approach to overcome curcumin's bioavailability limitations, advancing its clinical potential in oncology.