Exploring the mechanism of Panax notoginseng saponin in inhibiting the inflammatory response of microglia in cerebral ischemia based on network pharmacology

• PNS inhibits microglia-mediated neuroinflammation in cerebral ischemia, offering a potential therapeutic strategy for ischemic stroke. • Network pharmacology identifies key targets and pathways, revealing the multi-target mechanism of PNS in IS. • PNS reduces the release of proinflammatory factors (iNOS, TNF-α, IL-1β, ROS) from activated microglia, mitigating brain damage. • The study provides a scientific basis for the clinical application of PNS in stroke prevention and treatment.