Official PDF Translation•Acta Biochimica et Biophysica Sinica

Exosomal integrin alpha 3 promotes epithelial ovarian cancer cell migration via the S100A7/p-ERK signaling pathway

Authors: Zeyuan Yin; Jiachen Ma; Joseph Adu-Amankwaah; Guangyan Xie; Yinghao Wang; Wei Tai; Zhenquan Sun; Chuting Huang; Guanfeng Chen; Tong Fu; Bei Zhang; Xueyan Zhou

DOI: 10.3724/abbs.2025024Status: Verified Translated Edition

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Key Findings in This Report

• Exosomal ITGA3 is identified as a key promoter of epithelial ovarian cancer cell migration, with high expression linked to poor prognosis. • ITGA3 is transferred via exosomes to recipient cells, where it activates the S100A7/p-ERK signaling pathway to drive migration. • In vivo studies confirm that ITGA3-enriched exosomes enhance tumor growth and migration, while ITGA3 knockdown attenuates these effects. • The ITGA3/S100A7 axis represents a novel prognostic biomarker and potential therapeutic target for improving EOC patient outcomes.