Exercise regulation of pyroptosis for the prevention and treatment of bone metabolic disorders

• Pyroptosis, a pro-inflammatory programmed cell death, contributes to bone metabolic disorders by releasing inflammatory cytokines that disrupt bone remodeling. • Exercise inhibits pyroptosis through multiple mechanisms, including suppression of NLRP3 inflammasome activation, reduction of pyroptotic protein expression, and modulation of myokine secretion. • Exercise-induced inhibition of pyroptosis leads to decreased osteoclast activity and increased osteoblast activity, thereby improving bone mass and joint health. • Regular exercise represents a promising non-pharmacological strategy for preventing and treating osteoporosis, osteoarthritis, and rheumatoid arthritis by targeting pyroptosis.