EOAI3402143 inhibits lung adenocarcinoma progression through the NF-κB/NR4A1 pathway

• EOAI3402143 promotes apoptosis and inhibits migration, invasion, and proliferation of LUAD cells. • Mechanistically, EOAI3402143 suppresses the NF-κB pathway and downregulates NR4A1 expression. • In vivo studies demonstrate that EOAI3402143 exhibits potent antitumor efficacy against LUAD. • EOAI3402143 represents a promising novel therapeutic agent for lung adenocarcinoma.