Enhancing the Anticancer Activity of Natural Products through Combination with Synthetic Agents: A Review

• Combination therapy of natural products and synthetic agents shows enhanced anticancer activity through synergistic mechanisms. • These combinations can overcome drug resistance and reduce systemic toxicity compared to monotherapy. • Key pathways involved include apoptosis, cell cycle arrest, and inhibition of angiogenesis. • Rational design and optimization are crucial for translating these combinations into effective clinical treatments.