Effects of protein kinase C on the expression of myocardial SarcKATP channels in model rats during exercise preconditioning

• Protein kinase C differentially regulates Kir6.2 and SUR2A expression in early vs. late exercise preconditioning. • Inhibition of protein kinase C alters mRNA and protein levels of SarcKATP channel subunits in a phase-specific manner. • The regulatory effects of protein kinase C on Kir6.2 and SUR2A are coordinated and complementary across early and late preconditioning. • These findings provide insights into the molecular mechanisms underlying exercise-induced cardioprotection.