• Platelet-rich fibrin significantly enhances new bone formation and implant-bone contact in a rat model of peri-implant bone defect.
• PRF upregulates osteogenic gene expression (Runx2, osteocalcin, osteopontin) and improves bone microarchitecture.
• PRF modulates the IKK/IκB/NF-κB signaling pathway, reducing inflammatory protein expression.
• PRF promotes bone healing and may serve as an effective therapeutic strategy for peri-implant bone defects.