Druggable gene and single cell analyses reveal potential therapeutic targets for osteoporosis

• Identified 37 druggable genes associated with osteoporosis, with troponin C2 and CXCR6 showing protective effects and shared causal variants. • CXCR6 expression was significantly reduced in osteoporosis, and single-cell analysis revealed its predominant expression on T cells with enhanced cell communication. • Drug enrichment and molecular docking identified NSC95397 as a potential CXCR6-targeting compound with good binding activity. • The study provides novel insights into osteoporosis pathogenesis and potential therapeutic targets, supporting translational applications.