Official PDF Translation•Acta Biochimica et Biophysica Sinica

DPP3 promotes breast cancer tumorigenesis by stabilizing FASN and promoting lipid synthesis

Authors: Xiaoyu Fu; Xu Li; Weixing Wang; Juanjuan Li

DOI: 10.3724/abbs.2024054Status: Verified Translated Edition

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Key Findings in This Report

• DPP3 is overexpressed in breast cancer tissues and correlates with poor patient survival, suggesting its potential as a prognostic biomarker. • Knockout of DPP3 in breast cancer cell lines inhibits proliferation and migration while promoting apoptosis, indicating its oncogenic role. • DPP3 stabilizes FASN, enhancing fatty acid synthesis and contributing to metabolic reprogramming in tumors. • The DPP3-FASN interaction represents a novel therapeutic target for breast cancer treatment.