Degradation characteristics and biotoxicity of new domestic polyglycolic acid neural catheter

• The new domestic polyglycolic acid neural catheter exhibits degradation characteristics similar to the imported Neurotube® catheter. • In vitro degradation of the new catheter has minimal impact on pH under fluid exchange conditions, but can lower pH under non-exchange conditions. • The new catheter does not affect the proliferation or migration of human fibroblasts, indicating good cytocompatibility. • In vivo implantation in rats shows no obvious toxicity to major organs and no inflammatory cell infiltration, confirming its biosafety.