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Official PDF TranslationStem Cell Research & Therapy

Correction: Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models

Authors: Mathew Blurton-Jones; Brian Spencer; Sara Michael; Nicholas A. Castello; Andranik A. Agazaryan; Joy L. Davis; Franz-Josef Müller; Jeanne F. Loring; Eliezer Masliah; Frank M. LaFerla

DOI: 10.1186/s13287-024-03702-7Status: Verified Translated Edition
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Key Findings in This Report

• This correction addresses an artifact in Fig. 6H of the original article, ensuring accurate representation of data. • The corrected image clarifies the effects of sNEP-NSC transplantation on amyloid pathology in a second transgenic AD model. • The study underscores the potential of genetically modified neural stem cells expressing neprilysin as a therapeutic strategy for Alzheimer's disease. • The correction maintains the integrity of the original findings, which showed reduced plaque pathology and synaptotoxicity.