Official PDF Translation•Acta Biochimica et Biophysica Sinica

circ_0006156 promotes esophageal squamous cell carcinoma progression via activation of the TGFβ/Smad pathway

Authors: Zhanpeng Tang; Jian Li; Rongyang Li; Luyuan Ma; Renchang Zhao; Zhenguo Sun; Hui Tian

DOI: 10.3724/abbs.2026049Status: Verified Translated Edition

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Key Findings in This Report

• circ_0006156 is significantly upregulated in ESCC tissues and cell lines, correlating with poor overall survival. • circ_0006156 acts as a sponge for miR-202-5p, relieving its suppression on TGFBR1 and activating the TGFβ/Smad pathway. • Knockdown of circ_0006156 inhibits ESCC cell proliferation, migration, and invasion in vitro and tumor growth in vivo. • circ_0006156 represents a potential novel biomarker and therapeutic target for ESCC.