CD40 ligation-induced ERK activation leads to enhanced radiosensitivity in cervical carcinoma cells via promoting autophagy

• CD40 ligation promotes autophagosome formation and autophagic flux in cervical cancer cells, enhancing radiosensitivity. • The mechanism involves ERK-mediated upregulation of ATG13 via p53, linking CD40 signaling to autophagy regulation. • This study provides novel evidence that CD40 pathway activation can sensitize cervical cancer cells to radiotherapy. • Findings suggest potential therapeutic strategy combining CD40 activation with radiotherapy for cervical cancer treatment.