• CD19 on CD24+CD27+ B cells is a protective factor for platinum drug efficacy (OR=0.598, P=0.004).
• HLA-DR+CD8+ T cell percentages protect against liver injury from platinum drugs.
• CD39 on CD39+ secreting CD4+ regulatory T cells and CD3 on CD39+ resting CD4 regulatory T cells are risk factors for renal injury.
• B cell-related traits influence gastrointestinal and cutaneous toxicity, while T cell-related traits affect other adverse outcomes.