Cardioprotective effect of Saussurea involucrata injection against Doxorubicin-induced cardiotoxicity by network pharmacology analysis and experimental verification

• SII significantly improves Dox-induced cardiac dysfunction and reduces pathological alterations and fibrosis in cardiomyocytes. • SII exerts cardioprotective effects by attenuating inflammation, oxidative stress, and apoptosis triggered by Dox. • Network pharmacology reveals that SII downregulates P53 expression via activation of the AKT/MDM2 signaling pathway. • SII represents a promising therapeutic strategy for alleviating Doxorubicin-induced cardiotoxicity.