• Buzhong Yiqi Decoction (BYD) accelerates skeletal muscle regeneration in a cardiotoxin-induced injury model.
• BYD treatment reduces immune cell infiltration at 5 days post-injury, indicating an anti-inflammatory effect during acute muscle injury.
• BYD significantly increases the size of regenerating myofibers at 7 and 14 days post-injury, suggesting enhanced muscle repair.
• These findings provide experimental evidence supporting the potential of BYD as a therapeutic approach for muscle degenerative diseases.