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Official PDF TranslationActa Biochimica et Biophysica Sinica

Bronchial thermoplasty decreases airway remodeling by inhibiting autophagy via the AMPK/mTOR signaling pathway

Authors: Tao Wang; Peng Fu; Wenting Huang; Liang Long; Fa Long; Shengming Liu

DOI: 10.3724/abbs.2024028Status: Verified Translated Edition
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Key Findings in This Report

• BT reduces airway remodeling by suppressing autophagy in human airway smooth muscle cells. • Thermal effects from BT decrease HASMC proliferation and increase apoptosis. • BT inhibits autophagy via downregulation of the AMPK/mTOR signaling pathway. • AMPK agonist or mTOR antagonist reverses BT's effects, confirming pathway involvement.