• A total of 558 publications on mitochondria and spinal cord injury treatment were analyzed, revealing a steady increase in research output from 1990 to 2024.
• The United States and China are leading contributors in this field, with high publication counts, citation frequencies, and influential research institutions.
• Current research hotspots focus on apoptosis and oxidative stress, while future directions may explore molecular mechanisms, inflammation, and neural repair.
• Despite progress, the field faces challenges including limited high-quality literature and regional disparities in research development.
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