• Novel cell death modalities (pyroptosis, ferroptosis, necroptosis) are implicated in osteoarthritis pain pathogenesis.
• Targeting these cell death pathways may offer new therapeutic strategies for OA pain relief.
• Inflammatory responses, ROS production, and calcium ion levels are key mediators linking cell death to OA pain.
• Current OA pain treatments are inadequate, highlighting the need for novel mechanism-based interventions.