Official PDF Translation•Acta Biochimica et Biophysica Sinica

Atractylenolide I mitigates Alzheimer’s disease pathology in ApoE–/– mice via ARG1/nNOS axis and lipid homeostasis regulation

Authors: Xun Zhou; Rui Wang; Jingsi Yan; Xiaolang Wu; Dongsheng Yuan; Qi Wang; Huilin Li; Wei Zhao

DOI: 10.3724/abbs.2026055Status: Verified Translated Edition

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Key Findings in This Report

• AI treatment attenuates systemic lipid dyshomeostasis and cerebral lipid deposition in ApoE–/– mice. • AI suppresses neuroinflammation by downregulating M1 macrophage polarization markers. • AI restores cognitive function through neuronal preservation in hippocampal regions. • AI directly binds to ARG1, modulating arginine metabolism and the ARG1/nNOS axis.