Official PDF Translation•Chinese Journal of Tissue Engineering Research

Asiaticoside promotes osteogenic differentiation in osteoporotic rats

Authors: Xu Hongtao; Wang Jianping; Xu Yuehong; Li Qin; Qi Qihua; Xia Qipeng

DOI: 10.12307/2026.21560Status: Verified Translated Edition

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Key Findings in This Report

• Asiaticoside improves bone microarchitecture and histology in ovariectomized osteoporotic rats. • Asiaticoside reduces serum inflammatory cytokines (IL-1β, IL-18) and downregulates NLRP3 inflammasome components. • Asiaticoside promotes osteogenic differentiation of rat bone marrow mesenchymal stem cells in vitro. • The mechanism involves upregulation of TRIM24 and inhibition of NLRP3 expression.