• Artemisinin significantly improves myocardial blood perfusion in arsenic-poisoned rats, as evidenced by increased AUC and WIS×PI values on myocardial contrast echocardiography.
• Artemisinin reduces arsenic-induced myocardial microvascular damage and inflammation, indicated by decreased CD31 expression and restored myocardial ultrastructure.
• The protective effects of artemisinin are dose-dependent, with high-dose (60 mg/kg) showing greater efficacy than low-dose (30 mg/kg).
• This study provides a potential therapeutic strategy for arsenic-induced cardiotoxicity, highlighting artemisinin's dual antioxidant and anti-inflammatory actions.