• Hydrogels functionalized via physical, chemical, or biological modifications enhance biocompatibility, mechanical strength, and controlled degradation for bone tissue engineering.
• Functionalized hydrogels promote bone regeneration through cell interactions, growth factor signaling, mechanical microenvironment modulation, and drug/nano-delivery systems.
• Future hydrogels will integrate smart responsive modules (temperature, pH, enzyme, magnetic) for spatiotemporal control of bioactive factor release.
• High-precision 3D printing enables patient-specific scaffolds with controlled architecture and functional gradients for personalized bone defect repair.
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