• The overall incidence of adverse drug reactions (ADRs) after COVID-19 vaccination is 62.3%, with local reactions being the most common (78.5%).
• Serious ADRs are extremely rare (0.08%), confirming the overall safety of COVID-19 vaccines.
• Younger adults and females are more likely to experience ADRs, and mRNA vaccines are associated with a higher incidence of systemic reactions.
• The findings provide robust evidence to support the continued use of COVID-19 vaccines in public health campaigns.