Adverse Drug Reactions Associated with COVID-19 Vaccination: A Systematic Review and Meta-Analysis

• The overall incidence of any adverse drug reaction (ADR) after COVID-19 vaccination is 62.3%, with local reactions being most common. • Serious ADRs are extremely rare (0.02%), confirming the favorable safety profile of COVID-19 vaccines. • mRNA vaccines show a higher incidence of ADRs compared to viral vector vaccines, but both are generally well-tolerated. • These findings provide crucial evidence for healthcare providers and policymakers to reinforce vaccine confidence and informed consent.