• The novel hemodialysis protocol significantly improves urea reduction ratio (78.5% vs. 71.2%) and β2-microglobulin clearance (65.3% vs. 52.1%) compared to standard HD.
• Patients on the novel protocol experienced a 15% improvement in health-related quality of life and a 40% reduction in intradialytic hypotension episodes.
• Hospitalization rates were reduced by 25% in the novel protocol group, indicating better overall clinical outcomes.
• Personalized convective dialysis strategies offer a promising approach to enhance the efficacy and safety of hemodialysis in ESRD patients.