A new approach to intervene in Alzheimer's disease through regulating the silencing information regulator 1 signaling pathway with traditional Chinese medicine

• SIRT1 signaling pathway plays a crucial role in Alzheimer's disease by regulating energy metabolism, oxidative stress, neuroinflammation, autophagy, and apoptosis. • Traditional Chinese medicine monomers and compounds can activate SIRT1 signaling to protect neurons and delay AD progression. • Sodium ferulate improves cognitive function in AD rats by upregulating SIRT1 expression in the prefrontal cortex. • Oyster peptide alleviates oxidative damage and neuroinflammation in the hippocampus, enhancing synaptic function and neuronal survival.