Official PDF Translation•Chinese Journal of New Drugs

A Comprehensive Analysis of Hepatocellular Carcinoma Biomarkers: Integrating Transcriptomic and Proteomic Approaches for Early Diagnosis and Prognosis

Authors: ZHANG Wei; LI Ming; WANG Fang; CHEN Jie; LIU Yang; ZHAO Lei; SUN Hong; ZHOU Qiang

DOI: pub_80__articleID_190Status: Verified Translated Edition

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Key Findings in This Report

• Integrated transcriptomic and proteomic analysis identified a five-biomarker panel with 92% sensitivity and 88% specificity for early HCC detection. • A prognostic signature based on the biomarkers effectively stratifies HCC patients into distinct risk groups with significant survival differences. • Novel candidate biomarkers were validated in independent cohorts, demonstrating reproducibility and clinical utility. • The multi-omics approach offers a comprehensive framework for personalized HCC diagnosis and treatment.