Visualization Analysis of Knowledge Graph on Regulation of Mitochondrial Reactive Oxygen Species by Traditional Chinese Medicine Based on CiteSpace and VOSviewer
This bibliometric investigation systematically maps the research landscape of traditional Chinese medicine (TCM) interventions targeting mitochondrial reactive oxygen species (mtROS) from database inception to March 31, 2026. A total of 1,026 Chinese and 649 English articles were retrieved from CNKI, Wanfang, VIP, and Web of Science Core Collection. CiteSpace, VOSviewer, and Bibliometrix were employed to analyze annual publication output, countries, institutions, authors, journals, and keywords, including co-occurrence clustering and burst detection. Results demonstrate sustained growth in annual publications, with China dominating the field, though domestic and international collaboration networks remain fragmented. Core research institutions include Heilongjiang University of Chinese Medicine, Henan University of Chinese Medicine, and Guangxi University of Chinese Medicine. The most productive journals are Chinese Journal of Experimental Traditional Medical Formulae and Journal of Ethnopharmacology. Top Chinese keywords are oxidative stress, mitochondria, TCM, Chinese herbal medicine, and mechanisms of action; top English keywords are oxidative stress, apoptosis, activation, TCM, and reactive oxygen species. Keyword burst analysis reveals a research frontier transition from basic antioxidant mechanisms toward network pharmacology, molecular docking, and ferroptosis. These findings provide data-driven guidance for subsequent mechanistic studies and research planning, highlighting the need for strengthened cross-disciplinary cooperation.