Chinese Traditional and Herbal Drugs•2026•DOI: 10.7501/j.issn.0253-2670.2026.16.20261606
This study systematically investigated the dynamic changes in volatile components of Sichuan-origin Zingiberis Rhizoma Recens (ZRR) and its processed products—Ganjiang (ZR), Paojiang (ZRP), and Jiangtan (ZRC)—using electronic bionic sensing, gas chromatography-mass spectrometry (GC-MS), and molecular dynamics simulations. Electronic tongue analysis revealed significant taste differences among samples. GC-MS identified 15 common chemical constituents across all products, with 14 volatile compounds unique to ZRR, 8 to ZR, 1 to ZRP, and 5 to ZRC, predominantly terpenoids. Processing decreased monoterpene content while increasing most sesquiterpenes; elemol and curcumenol converted to β-elemene and α-curcumene. Molecular docking and dynamics simulations demonstrated that sesquiterpenes exhibited superior binding affinity to the TRPV1 pungent receptor compared to monoterpenes. β-Eudesmol and curcumenol formed stable hydrogen-bond networks with LEU-1383 and ILE-1441 residues of the 8GFA protein, governed primarily by van der Waals forces, electrostatics, and hydrogen bonding. These findings indicate that the enhanced pungency after processing is attributable to sesquiterpenoids, providing a molecular basis for the altered medicinal properties of processed ginger. The study acknowledges limitations regarding unclear transformation pathways and unexamined olfactory characteristics, suggesting future integration of metabolomics, cellular assays, and electronic nose technology.
Chinese Journal of Tissue Engineering Research•2026•DOI: 10.12307/2026.21372
BACKGROUND: The research results on TANK binding kinase 1, a bi-directional tumor regulator, have been increasing yearly, but there is no bibliometric literature to analyze the information in the literature related to TANK binding kinase 1. OBJECTIVE: To explore the research status, hot spots, and trends of TANK binding kinase 1 based on bibliometric analysis. METHODS: We collected literature related to TANK binding kinase 1 in the last 10 years based on the SCIE database in the Web of Science Core Collection. The data were imported into CiteSpace 6.3.R1 and analyzed bibliometrically and visually with five options: country, author, institution, reference, and keyword. In addition, Origin 2021 was used to plot the relevant statistical graphs. RESULTS AND CONCLUSION: There was an upward trend in the number of publications and co-citations involved in TANK binding kinase 1 research. Dan-Dan Chen, Jian-Fang Gui, Qiwei Qin, and Shun Li were the four authors with the highest number of publications (n=11), while the Chinese Academy of Sciences, University of Chinese Academy of Sciences, Zhejiang University, Chinese Academy of Agricultural Sciences, and Wuhan University had a larger number of publications (> 50). The research hot spots of TANK binding kinase 1 in the last decade mainly focus on innate immunity, the cyclic gmp-amp synthase (cGAS)-stimulator of interferon genes (STING) pathway, NF-κB, inflammation, optineurin, expression, and cancer. The results indicate that scholars from various countries have conducted continuous and in-depth research in related fields in recent years, and TANK binding kinase 1 shows great scientific potential in autoimmune systems, signaling pathways, gene expression, and tumor prevention and treatment. However, academic cooperation among scholars and institutions is not close, and future scholars should strengthen cooperation and communication, grasp the research hotspots and trends of TANK binding kinase 1, expand the scope of research in disease fields, and provide more evidence for further elucidating the pharmacological mechanisms and pathological changes of diseases.