Analysis of Acid-Base Complexation Reaction Patterns of Salvianolic Acid B and Matrine During Compatibility of Salviae Miltiorrhizae Radix et Rhizoma and Sophorae Flavescentis Radix Based on a Quantitative Model of Component States
A confined mass transfer mathematical model was constructed to quantify the existing states of matrine in complex traditional Chinese medicine solutions and to resolve the influence of Salviae Miltiorrhizae Radix et Rhizoma (SMRR) to Sophorae Flavescentis Radix (SFR) compatibility ratios on acid-base complexation. Ultrafiltration-nanofiltration coupling exploited mass transfer differences between ionic and molecular states, using component transmission rate and membrane flux to fit matrine mass transfer coefficients. Molecular and ionic monomer references established a power-function quantitative model with correlation coefficients exceeding 0.97. In SFR extract alone, matrine distributed as 36.90% ionic, 61.98% associated, and 1.12–1.91% molecular states. Upon SMRR compatibility, the ionic fraction declined from 66.73% at low SMRR ratios to 45.83% at high SMRR ratios, while the complex state increased from 31.87% to 52.90%. Dynamic light scattering and scanning electron microscopy confirmed microstructural transitions. The model addresses the limitation of empirical pharmaceutical parameter control that neglects state-dependent mass transfer differences, providing a technical foundation for ordered production regulation linking manufacturing parameters, component states, and material transfer to improve batch-to-batch uniformity and stability of Chinese medicine preparations.