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Verified CAS / Academic Author2 Decoded Studies

Prof. WANG Xiaofen

Jiangxi University of Chinese Medicine

Research Publications & English Decoded Briefs

Showing 2 publications
Acta Biochimica et Biophysica Sinica•2024•DOI: 10.3724/abbs.2024180

SMG-1 serves as a prognostic indicator for the radiotherapy response in head and neck squamous cell carcinoma xenografts and patients

Head and neck squamous cell carcinoma (HNSCC) is a common malignancy where radiotherapy is a primary treatment. The prognostic value of SMG-1, a PIKK family member involved in DNA damage response, remains controversial. This study investigated SMG-1 expression in HNSCC and its impact on tumor growth, prognosis, and radiosensitivity. Using bioinformatics analysis, we found elevated SMG-1 mRNA in HNSCC tissues. Knockdown of SMG-1 in SCC-090 cells did not affect proliferation in vitro or tumor growth in xenografts. In a cohort of 36 radiotherapy-naïve HNSCC patients, SMG-1 protein expression did not correlate with overall survival. However, SMG-1 knockdown enhanced radiosensitivity in vitro, suggesting SMG-1 as a potential prognostic indicator for radiotherapy response. These findings highlight the need for further validation in larger clinical cohorts.

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Chinese Traditional and Herbal Drugs•2026•DOI: 10.7501/j.issn.0253-2670.2026.15.20261512

Casticin Improves Colitis-Associated Colorectal Cancer by Regulating Gut Microbiota-Mediated Complement and Coagulation Cascades

Casticin, a polymethoxyflavone derived from Vitex trifolia, was evaluated for its therapeutic efficacy and mechanism in colitis-associated colorectal cancer (CAC) using an azoxymethane/dextran sulfate sodium (AOM/DSS) mouse model. Casticin intervention significantly attenuated body weight loss, reduced disease activity index, and decreased colonic tumor volume and tumor burden (P < 0.05), while improving survival rates of tumor-bearing mice. Safety assessments revealed no significant abnormalities in serum liver function indicators or major organ histomorphology. 16S rRNA sequencing demonstrated that casticin reversed CAC-induced gut dysbiosis, notably downregulating the pro-carcinogenic phyla Fusobacteriota and Patescibacteria, and enriching anti-inflammatory short-chain fatty acid-producing genera Lachnospiraceae_NK4A136_group and Prevotellaceae_UCG-001. Proteomic profiling identified the complement and coagulation cascades as the core responsive pathway, with dose-dependent restoration of serine protease inhibitor 1 (Serpine1) and integrin alpha M (Itgam) expression. Western blotting confirmed significant downregulation of Itgam and Serpine1 in colonic tissue (P < 0.01 and P < 0.001, respectively), consistent with proteomic trends. Correlation analysis further revealed that beneficial genera such as Lachnospiraceae_NK4A136_group were negatively correlated with Serpine1 expression, whereas pro-carcinogenic Fusobacteriota was positively correlated with Itgam expression. These findings indicate that casticin ameliorates CAC by remodeling gut microbiota composition and modulating key molecules in the complement and coagulation cascades, thereby synergistically blocking the inflammation-to-cancer transition.

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